917236-93-2Relevant academic research and scientific papers
Stereochemically general approach to adjacent bis(tetrahydrofuran) cores of annonaceous acetogenins
Wysocki, Laura M.,Dodge, Matthew W.,Voight, Eric A.,Burke, Steven D.
, p. 5637 - 5640 (2007/10/03)
A series of six 2,5-disubstituted adjacent bis(tetrahydrofuran) stereoisomers with trans/erythro/cis, trans/threo/trans, or cis/threo/cis relative stereochemistry have been synthesized from known dihydroxycyclooctenes via ring opening/cross metathesis and Pd(0)-mediated asymmetric double cycloetherification. The stereochemistry of four of these isomers has been found in the biologically active annonaceous acetogenin natural products.
