917237-08-2Relevant academic research and scientific papers
MUSCARINIC AGONISTS
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Page/Page column 26-27, (2010/06/17)
Compounds of the general formula (I) and methods are provided for the treatment of disease conditions in which the modification of cholinergic, especially muscarinic receptor activity, has a beneficial effect. In the method, an effective amount of a compo
Synthesis and evaluation of dibenzothiazepines: A novel class of selective cannabinoid-1 receptor inverse agonists
Pettersson, Hanna,Bülow, Anne,Ek, Fredrik,Jensen, Jacob,Ottesen, Lars K.,Fejzic, Alma,Ma, Jian-Nong,Tredici, Andria L. Del,Currier, Erika A.,Gardell, Luis R.,Tabatabaei, Ali,Craig, Darren,McFarland, Krista,Ott, Thomas R.,Piu, Fabrice,Burstein, Ethan S.,Olsson, Roger
supporting information; experimental part, p. 1975 - 1982 (2009/12/31)
A novel class of CB1 inverse agonists was discovered. To efficiently establish structure-activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed. The compounds were evaluated in a mammalian cell-based func
USE OF CANNABINOID MODULATING COMPOUNDS IN COMBINATION WITH OTHER THERAPEUTIC COMPOUNDS FOR ADJUNCTIVE THERAPY
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Page/Page column 83-84, (2008/12/04)
The present invention relates to pharmaceutical compositions that contain a compound that modulate the activity of a cannabinoid receptor in conjunction with another therapeutic compound and uses of compounds that modulate the activity of a cannabinoid re
CB-1 MODULATING COMPOUNDS AND THEIR USE
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Page/Page column 53-54, (2008/06/13)
Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would
IRON CATALYZED CROSS-COUPLING REACTIONS OF IMIDOYL DERIVATIVES
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Page/Page column 37; 53, (2010/11/27)
Disclosed is a process for preparing a compound of formula A - N=C(D)(B), from a compound of formula A-N=C(E)(B) and a compound of formula D-M using an iron catalyst, where the process has is represented by Equation (I).
Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents
Ottesen, Lars K.,Ek, Fredrik,Olsson, Roger
, p. 1771 - 1773 (2007/10/03)
A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NM
