917240-80-3

Basic information

• Product Name: (+/-)-9-[(1-fluoromethyl)(3-(di-isopropyloxycarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS NO: 917240-80-3
• Molecular Weight: 823.812
• Mol File: 917240-80-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-9-[(1-fluoromethyl)(3-(di-isopropyloxycarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-9-[(1-fluoromethyl)(3-(di-isopropyloxycarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine(917240-80-3)
• EPA Substance Registry System: (+/-)-9-[(1-fluoromethyl)(3-(di-isopropyloxycarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine(917240-80-3)

Safety Data

• Hazardous Substances Data: 917240-80-3(Hazardous Substances Data)

Upstream product

• 889885-19-2 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-(diisopropylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-17-0 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-tert-butylcarbonyloxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-15-8 (+/-)-9-[(1-tert-butyldimethylsilyloxymethyl)(3-pivaloyloxy)propyl]adenine 
• 889885-16-9 (+/-)-9-[(1-hydroxymethyl)(3-tert-butylcarbonyloxy)propyl]adenine 
• 35180-01-9 chloromethyl isopropyl carbonate 
• 889885-18-1 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-hydroxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-36-3 (+/-)-9-[(1-fluoromethyl)(3-(diisopropylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-20-5 (+/-)-9-[(1-hydroxymethyl)(3-(diisopropylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 

Relevant articles and documents

Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents

□ Acyclic N9 adenine nucleosides substituted at C-1′ position were prepared by the Mitsunobu reaction of 1-tert-butyldimethylsilyl-4- pivaloylbutan-1,2,4-triol (5) with adenine. Pivaloyl hydroxyl was modified to the phosphonomethoxy derivatives, and the tert-butyldimethylsilyl hydroxyl was converted to methoxy, azido, amino, fluoro, and α-hydroxyethyl and was eliminated to give vinyl. The resulting phosphonic acids were converted to prodrugs also. Copyright Taylor & Francis Group, LLC.