917251-10-6

Basic information

• Product Name: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pent-4-en-1-ol
• Synonyms: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pent-4-en-1-ol
• CAS NO: 917251-10-6
• Molecular Weight: 292.494
• Mol File: 917251-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pent-4-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pent-4-en-1-ol(917251-10-6)
• EPA Substance Registry System: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pent-4-en-1-ol(917251-10-6)

Safety Data

• Hazardous Substances Data: 917251-10-6(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 917251-07-1 (3R)-1-phenyl-5-(tetrahydro-2H-2-pyranyloxy)-1-pentyl-3-ol 
• 917251-08-2 1-phenyl-5-(tetrahydro-pyran-2-yloxy)-pent-1-en-3-ol 

Downstream Products

• 917251-13-9 (R,2Z,6E)-5-hydroxy-7-phenylhepta-2,6-dienoate 
• 917251-12-8 (5R,2Z,6E)-5-(tert-butyldimethylsilanyloxy)-7-phenylhepta-2,6-dienoate 
• 917251-14-0 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-hept-6-enoic acid ethyl ester 
• 22639-28-7 (R)-goniothalamin 
• 735287-46-4 ethyl (E,R)-5-hydroxy-3-oxo-7-phenylhept-6-enoate 
• 917251-11-7 (3R,4E)-3-(tert-butyldimethylsilanyloxy)-5-phenylpent-4-enal 

Relevant articles and documents

Application of the Cosford cross-coupling protocol for the stereoselective synthesis of (R)-(+)-goniothalamin, (R)-(+)-kavain and (S)-(+)-7,8-dihydrokavain

An efficient and versatile synthetic method has been developed and utilized for the stereoselective synthesis of (R)-(+)-goniothalamin 1, (R)-(+)-kavain 2 and (S)-(+)-7,8-dihydrokavain 3. Application of the Cosford protocol and direct conversion of aldehydes to β-keto-esters are the key steps in our approach.