917252-80-3 Usage
Uses
Used in Pharmaceutical Industry:
6-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic Acid is used as an intermediate in the production of labelled Zolpidem metabolites for the following reasons:
1. It aids in the synthesis of labelled compounds that can be used as reference standards in analytical methods for the detection and quantification of Zolpidem and its metabolites in biological samples.
2. Labelled metabolites are essential for the development and validation of radioimmunoassays, enzyme-linked immunosorbent assays (ELISA), and other immunoassay techniques, which are crucial for monitoring drug levels and understanding drug metabolism.
3. The use of this intermediate contributes to the advancement of pharmaceutical research, particularly in the development of new drugs and therapies, as well as in the improvement of existing ones.
Check Digit Verification of cas no
The CAS Registry Mumber 917252-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,7,2,5 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 917252-80:
(8*9)+(7*1)+(6*7)+(5*2)+(4*5)+(3*2)+(2*8)+(1*0)=173
173 % 10 = 3
So 917252-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H16N2O4/c1-11-3-5-12(6-4-11)17-14(9-16(21)22)20-10-13(18(23)24-2)7-8-15(20)19-17/h3-8,10H,9H2,1-2H3,(H,21,22)
917252-80-3Relevant academic research and scientific papers
Klupsch, Frederique,Houssin, Raymond,Humbert, Luc,Imbenotte, Michel,Henichart, Jean-Pierre,Lhermitte, Michel
, p. 1318 - 1321 (2006)
An expeditious route to the two major metabolites of Zolpidem - and readily applicable to the synthesis of the drug - was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoacetophenone. The structures of the target compounds were confirmed from a 2D 1H- 15N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.
