91735-41-0Relevant academic research and scientific papers
C(6)-N(7)-Cyclized Purines
Griengl, H.,Hayden, W.,Plessing, A.
, p. 333 - 336 (2007/10/02)
By reaction of 6-aminopurine (2a) and of the corresponding 3-hydroxypropyl derivative 2b with thionyl chloride a bridge to N(1) is formed yielding 5 and 6, respectively, whereas from 6-aminopurine (2c) the 4-chlorobutyl compound 4 is obtained, which cyclizes in alkaline medium to the C(6)-N(7) bridged compound 7.A related cyclization to 11a-11f is observed when 6-chloropurines are reacted with 3-alkyl-1,3-oxazolidines or 3-methyl-1,3-thiazolidine.
