917377-75-4

Basic information

• Product Name: (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene
• Synonyms: (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene;(R)-(+)-7,7'-Bis[di(3,5-diMethylphenyl)phosphino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane (R)-Xyl-SDP
• CAS NO: 917377-75-4
• Molecular Formula: C₄₉H₅₀P₂
• Molecular Weight: 700.868822
• Product Categories: BINAP Series;Chiral Phosphine;Chiral Spiro Ligand
• Mol File: 917377-75-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 794.8±60.0 °C(Predicted)
• Appearance: off-white to pale yellow/solid
• Storage Temp.: ?20°C
• Sensitive: air sensitive
• CAS DataBase Reference: (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene(917377-75-4)
• EPA Substance Registry System: (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene(917377-75-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 917377-75-4(Hazardous Substances Data)

Usage

Description

(R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene is a chiral ligand that is commonly used in organic synthesis and catalysis. It consists of two phosphine groups attached to a spirobiindene backbone, resulting in a bulky and highly asymmetric structure. This ligand is known for its ability to impart high enantioselectivity in various chemical reactions, particularly in transition metal-catalyzed asymmetric transformations. It has been widely utilized in the synthesis of pharmaceuticals, natural products, and other fine chemicals. Overall, (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene is a valuable tool in the field of organic chemistry for achieving stereochemically pure compounds.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene is used as a chiral ligand for the synthesis of pharmaceuticals, enabling the production of enantiomerically pure compounds. Its high enantioselectivity is crucial for the development of drugs with improved efficacy and reduced side effects.
Used in Natural Product Synthesis:
In the field of natural product synthesis, (R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene is used as a chiral ligand to facilitate the production of complex molecules with specific stereochemistry. This is essential for the development of new drugs and the study of biologically active compounds.
Used in Fine Chemicals Industry:
(R)-(+)-7,7′-Bis[di(3,5-dimethylphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobiindene is employed as a chiral ligand in the synthesis of fine chemicals, which are high-purity specialty chemicals used in various applications such as fragrances, flavors, and agrochemicals. Its ability to impart high enantioselectivity ensures the production of high-quality enantiomerically pure products.