917591-95-8Relevant academic research and scientific papers
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy
Sriram, Madhavi,Hall, John J.,Grohmann, Nathan C.,Strecker, Tracy E.,Wootton, Taylor,Franken, Andreas,Trawick, Mary Lynn,Pinney, Kevin G.
, p. 8161 - 8171 (2008/12/23)
A novel series of dihydronaphthalene and benzosuberene analogs bearing structural similarity to the combretastatins in terms of 1,2-diarylethene, trimethoxyphenyl, and biaryl functionality has been synthesized. The compounds have been evaluated in regard
Combretastatin analogs with tubulin binding activity
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Page/Page column 30, (2008/06/13)
Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
