917598-46-0

Basic information

• Product Name: 2(1H)-Pyrimidinone, tetrahydro-5-(phenylmethoxy)-1,3-bis(phenylmethyl)-
• CAS NO: 917598-46-0
• Molecular Formula: C25H26N2O2
• Molecular Weight: 386.494
• Mol File: 917598-46-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrimidinone, tetrahydro-5-(phenylmethoxy)-1,3-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, tetrahydro-5-(phenylmethoxy)-1,3-bis(phenylmethyl)-(917598-46-0)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, tetrahydro-5-(phenylmethoxy)-1,3-bis(phenylmethyl)-(917598-46-0)

Safety Data

• Hazardous Substances Data: 917598-46-0(Hazardous Substances Data)

Upstream product

• 1852-18-2 tetrahydro-5-hydroxy-2(1H)-pyrimidinone 
• 100-44-7 benzyl chloride 

Relevant articles and documents

New AZT conjugates as potent anti-HIV agents

In an attempt to discover anti-HIV agents with much reduced cytotoxicity from the currently available HIV-reverse transcriptase inhibitors, AZT conjugates of cholanic acids, 2-imidazolidone-4-carboxylic acid and its derivatives, and N,N′-disubstituted 5-hydroxy-tetrahydropyrimidin-2-ones have been synthesized and their anti-HIV profiles determined with CEM-SS cell line. The AZT conjugates with 2-imidazolidone-4-carboxylic acid and 2-pyrrolidone-5-carboxylic acid through an ester linkage, and with N,N′-diphenyl-5-hydroxy-tetrahydropyrimidin-2-one through a succinate tether showed significantly higher therapeutic indexes than AZT while they also retained or enhanced AZT's anti-HIV activity. Thus, structural features that favor the desired therapeutic profile of the conjugates appear to include a five-membered ring cyclic urea or lactam, and six-membered ring cyclic urea with N,N′-diphenyl substitution. Copyright Taylor & Francis Group, LLC.