917607-71-7Relevant articles and documents
Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I
Diana, Patrizia,Martorana, Annamaria,Barraja, Paola,Montalbano, Alessandra,Dattolo, Gactano,Cirrincione, Girolamo,Dall'Acqua, Francesco,Salvador, Alessia,Vedaldi, Daniela,Basso, Giuseppe,Viola, Giampietro
, p. 2387 - 2399 (2008)
Isoindoloquinoxalines 4 and 5 were obtained by refluxing 2-(2′-aminoaryl)-1-cyanoisoindoles 3a-e in acetic or formic acid. All derivatives were screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay aga
ISOINDOLO-QUINOXALINE DERIVATIVES HAVING ANTITUMOR ACTIVITY, PROCESS FOR THEIR PRODUCTION AND THEIR USE
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Page/Page column 15-16; 18, (2008/06/13)
New isoindolo[2,1-a]quinoxaline derivatives of general formula (1 ), wherein R represents H or OH and R5 represents H or CN, have been prepared with simple procedures starting from known intermediates and resulted to posses potent in vitro anti