917614-64-3

Upstream product

• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 917614-79-0 1-(1-{2-[trans-2-(4-fluorophenyl)-vinyl]-3-nitrobenzoyl}-piperidin-4-yl)-1,3-dihydro-benzimidazol-2-one 
• 917614-83-6 {2-[trans-2-(4-fluorophenyl)-vinyl]-3-nitrophenyl}-pyrrolidin-1-yl-methanone 
• 917614-84-7 [2-(4-fluorophenyl)-1H-indol-4-yl]-pyrrolidin-1-yl-methanone 

Relevant academic research and scientific papers

Preparation of 2-arylindole-4-carboxylic amide derivatives

A practical, highly efficient protocol has been developed for the synthesis of functionalized 2-arylindole-4-carboxylic amide derivatives. Commercially available methyl 2-methyl-3-nitrobenzoate gave substituted nitrostyrene benzoic acids by reaction with aromatic aldehydes in the presence of DBU in DMSO. Conversion of these products to the desired amides was followed by Pd-catalyzed reductive cyclization employing carbon monoxide as the terminal reductant to provide the 2-arylindole-4-carboxylic amide derivatives in excellent overall yield for the simple three-step sequence.