91766-21-1

Basic information

• Product Name: diethyl (3-oxocyclopentyl)propanedioate
• Synonyms: Diethyl (3-oxocyclopentyl)malonate; propanedioic acid, 2-(3-oxocyclopentyl)-, diethyl ester
• CAS NO: 91766-21-1
• Molecular Formula: C₁₂H₁₈O₅
• Molecular Weight: 242.2683
• Mol File: 91766-21-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 320.4°C at 760 mmHg
• Flash Point: 138.1°C
• Density: 1.151g/cm³
• Vapor Pressure: 0.000318mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: diethyl (3-oxocyclopentyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (3-oxocyclopentyl)propanedioate(91766-21-1)
• EPA Substance Registry System: diethyl (3-oxocyclopentyl)propanedioate(91766-21-1)

Safety Data

• Hazardous Substances Data: 91766-21-1(Hazardous Substances Data)

Upstream product

• 930-30-3 cyclopent-2-enone 
• 685-87-0 Diethyl 2-bromomalonate 
• 1196977-39-5 C₁₃H₁₈O₅ 
• 120-92-3 cyclopentanone 
• 105-53-3 diethyl malonate 

Downstream Products

• 62457-60-7 Ethyl 2-(3-oxocyclopentyl)acetate 
• 3128-05-0 (3-oxo-cyclopentyl)-acetic acid 

Relevant articles and documents

Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids

A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.

Expedient synthesis of 3-substituted cycloalkanones via a Pd-catalyzed decarboxylative protonation protocol

We developed an efficient method for the introduction of -CH2EWG moiety at the β-position of 2-cycloalken-1-ones via a Pd-catalyzed decarboxylative protonation protocol.

Lewis acid catalyzed conjugate addition and the formation of heterocycles using Michael acceptors under solvent-free conditions

Conjugate addition and conjugate-addition-initiated ring closure (CAIRC) reactions of β-dicarbonyl compounds with Michael acceptors have been studied using several Lewis acid catalysts under solvent-free conditions. Excellent chemoselectivity was obtained when various Michael acceptors were treated with several β-dicarbonyl compounds. On the other hand, 2-bromo-2-cyclopentenone and 3-bromo-3-vinyl methyl ketone furnished 2,3-dihydrofurans instead of the 1,4-adducts when treated with the same reagents. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.