917758-91-9Relevant academic research and scientific papers
Optimization of pharmacokinetics through manipulation of physicochemical properties in a series of HCV inhibitors
Lazerwith, Scott E.,Bahador, Gina,Canales, Eda,Cheng, Guofeng,Chong, Lee,Clarke, Michael O.,Doerffler, Edward,Eisenberg, Eugene J.,Hayes, Jaclyn,Lu, Bing,Liu, Qi,Matles, Mike,Mertzman, Michael,Mitchell, Michael L.,Morganelli, Philip,Murray, Bernard P.,Robinson, Margaret,Strickley, Robert G.,Tessler, Megan,Tirunagari, Neeraj,Wang, Jianhong,Wang, Yujin,Zhang, Jennifer R.,Zheng, Xubin,Zhong, Weidong,Watkins, William J.
, p. 715 - 719 (2011/12/01)
A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of comp
2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
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Page/Page column 70-71, (2010/04/03)
Pyrido(3,2-d)pyrimidine derivatives represented by the structural formuia (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro
PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
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Page/Page column 55-56, (2008/12/06)
Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (I), wherein: R4 is hydrogen, and R1, R2 and R3 together provide a specific substitution pattern, pharmaceutical acceptable addition salt
