917837-69-5Relevant academic research and scientific papers
Bio-based triacetic acid lactone in the synthesis of azaheterocycles via a ring-opening transformation
Obydennov, Dmitrii L.,El-Tantawy, Asmaa I.,Sosnovskikh, Vyacheslav Ya.
, p. 8943 - 8952 (2018/06/08)
In the present article a new way of converting bio-based triacetic acid lactone (TAL) into azaheterocyclic compounds, such as 4-pyridones, pyrazoles, isoxazolines and isoxazoles, has been found. The main strategy involves the transformation of TAL into re
Straightforward transformation of isoxazoles into pyrazoles: renewed and improved
Sviridov, Sergey I.,Vasil'ev, Andrei A.,Shorshnev, Sergey V.
, p. 12195 - 12201 (2008/02/11)
Isoxazoles bearing alkyl or carbamoyl groups were transformed into the corresponding pyrazoles in high yields by the treatment with hydrazine in methanol in the presence of a hydrogenation catalyst, e.g., Raney nickel, at ambient temperature. For the synthesis of N-substituted pyrazoles, hydrogenolysis of isoxazole followed by the treatment with substituted hydrazine was required. 3(5)-Aryl- or acylamido-substituted isoxazoles are less suitable for such transformations.
Substituted enaminones, their derivatives and uses thereof
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Page/Page column 13, (2010/11/25)
The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a
