917951-47-4Relevant academic research and scientific papers
A palladium-catalysed urea arylation route to a CRF1 receptor antagonist
Popkin, Matthew E.,Bellingham, Richard K.,Hayes, Jerome F.
, p. 2716 - 2718 (2008/02/11)
A new synthetic approach to a potent CRF antagonist, GW808990 (NBI35583), is reported. The route hinges on the palladium-catalysed intramolecular arylation of a urea with 2-chloropyridine. Spontaneous piperazine ring closure means that a high-yielding bis
