917952-93-3Relevant academic research and scientific papers
Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia
Ma, Chaoqun,Chen, Jianghui,Xing, Dong,Sheng, Yuan,Hu, Wenhao
supporting information, p. 2854 - 2857 (2017/03/11)
An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62?:?38 dr.
Iron porphyrins catalyze the synthesis of non-protected amino acid esters from ammonia and diazoacetates
Aviv, Iris,Gross, Zeev
, p. 4477 - 4479 (2008/09/19)
Iron complexes of porphyrins (and corroles to a lesser extent) are the first catalysts to utilize ammonia for the synthesis of N-free amino acid esters. The Royal Society of Chemistry 2006.
