91797-35-2Relevant academic research and scientific papers
The use of chiral dithianes for the synthesis of chiral α-oxo-β-alkyl and chiral α-oxo-β-aryl esters
Tyrrell, Elizabeth,Skinner, George A.,Janes, John,Milsom, Greig
, p. 1073 - 1076 (2007/10/03)
A number of chiral dithianes were synthesised using chiral auxiliary technology. These were then used as acyl anion equivalents in the synthesis of chiral α-oxo-β-alkyl and chiral α-oxo-β-aryl esters.
Syntheses of isotopically labelled L-?±-amino acids with an asymmetric centre at C-3
Harding, John R.,Hughes, Rachael A.,Kelly, Nicholas M.,Sutherland, Andrew,Willis, Christine L.
, p. 3406 - 3416 (2007/10/03)
Approaches are described to the synthesis of a series of isotopically labelled L-a-amino acids each with an asymmetric centre at C-3, including isoleucine, allo-isoleucine, threonine and allo-threonine. The methods may be simply adapted for the selective incorporation of an isotopic label at each site of L-valine including the selective labelling of either diastereotopic methyl group with carbon-13 and/or deuterium and labelling of the amine with nitrogen-15. ? The Royal Society of Chemistry 2000.
Chemo-enzymatic synthesis of isotopically labelled L-valine, L-isoleucine and allo-isoleucine
Kelly, Nicholas M.,Reid, R. Gordon,Willis, Christine L.,Winton, Peter L.
, p. 1517 - 1520 (2007/10/03)
Syntheses of (3R)-[4,4,4-D3]-L-valine, [15N]-L-isoleucine and [15N]-allo-isoleucine from homochiral 2-alkylated carboxylic acids are described. The approach involves a one-carbon homologation of the carboxylic acid to give
