917989-63-0Relevant academic research and scientific papers
Total Synthesis of (+)-Cornexistin
Barber, David M.,Magauer, Thomas,Steinborn, Christian,Wildermuth, Raphael E.
, p. 17282 - 17285 (2020/08/21)
Herein, we describe the first total synthesis of (+)-cornexistin as well as its 8-epi-isomer starting from malic acid. The robust and scalable route features a Nozaki–Hiyama–Kishi reaction, an auxiliary-controlled syn-Evans-aldol reaction, and a highly efficient intramolecular alkylation to form the nine-membered carbocycle. The delicate maleic anhydride moiety of the nonadride skeleton was constructed from a β-keto nitrile. The developed route enabled the synthesis of 165 mg (+)-cornexistin.
An approach to triquinane synthesis using the Pauson-Khand reaction
Krafft, Marie E.,Kyne, Graham M.,Hirosawa, Chitaru,Schmidt, Peter,Abboud, Khalil A.,L'Helias, Nathalie
, p. 11782 - 11792 (2007/10/03)
Tricyclic skeletons have been generated from acyclic enyne precursors by using an intramolecular Pauson-Khand reaction in combination with aldol, Michael and alkylation reactions.
