91799-75-6Relevant academic research and scientific papers
Microwave assisted urea-acetic acid catalyzed knoevenagel condensation of ethyl cyanoacetate and 1,3-Thiazolidine-2,4-dione with aromatic aldehydes under solvent free condition
Tryambake, Pravin. T.
, p. 2401 - 2405 (2017)
Knoevengel condensation reaction of various aromatic aldehydes with ethyl cyanoacetate and 1,3-thiazolidinone-2,4-diones catalyzed by urea-acetic acid under solvent free condition where olefinic products were obtained in high yield within short reaction time.
Synthesis and evaluation of thiazolidinedione-coumarin adducts as antidiabetic, anti-inflammatory and antioxidant agents
Mishra, Garima,Sachan, Narsingh,Chawla, Pooja
, p. 429 - 445 (2016/03/25)
In the present research work, ten novel thiazolidine-2,4-dione-coumarin adducts were synthesized using three step reaction procedure. Firstly, benzylidene thiazolidinediones (II) were synthesized by facile Knoevenagel condensation reaction using various substituted aldehydes, thiourea and chloroacetic acid. Further, 3-bromoacetyl coumarins (IV) were synthesized using salicylaldehyde and ethylacetoacetate in the presence of piperidine as a catalyst forming 3-acetylcoumarin (III) which was brominated to form 3-bromoacetyl coumarin. Finally, both these compounds i.e., (II) and (IV) were condensed in the presence of dimethyl formamide and potassium carbonate leading to the formation of novel thiazolidine-2,4-dione-coumarin adducts. The synthesized compounds were screened for different biological activities. Antioxidant activity was performed in-vitro by three different methods namely FRAP (Ferric ion reducing antioxidant power) method, DPPH (1,1-diphenyl-2-picrylhydrazyl) method and hydrogen peroxide scavenging assay method using ascorbic acid as a standard. Among the synthesized compounds, FP10 and FP9 emerged as breakthrough antioxidant agents. Furthermore, the compounds were checked for their anti-inflammatory and antidiabetic activity in which compounds FP7 and FP1 showed promising anti-inflammatory and antidiabetic potential in-vivo, and may be used as lead compound for future studies.
Sonochemistry: A good, fast and clean method to promote the synthesis of 5-arylidene-2,4-thiazolidinediones
Drawanz, Bruna B.,Ribeiro, Camila S.,Masteloto, Hellen G.,Neuenfeldt, Patrícia D.,Pereira, Claudio M.P.,Siqueira, Geonir M.,Cunico, Wilson
, p. 1615 - 1617 (2014/06/09)
The efficient synthesis of sixteen 5-arylidene-2,4-thiazolidinediones by aldol condensation reaction of 2,4-thiazolidinedione, mono- and di-substituted arenealdehydes and KOH using ultrasound irradiation is reported. The desired compounds were obtained in
