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91803-38-2

2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 91803-38-2 Structure

  • Basic information

    1. Product Name: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE
    2. Synonyms: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE;2-(3,5-DIMETHYL-PYRAZOL-1-YL)-3H-QUINAZOLIN-4-ONE
    3. CAS NO:91803-38-2
    4. Molecular Formula: C13H12N4O
    5. Molecular Weight: 240.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 91803-38-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE(91803-38-2)
    11. EPA Substance Registry System: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)QUINAZOLIN-4(3H)-ONE(91803-38-2)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 91803-38-2(Hazardous Substances Data)

91803-38-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 91803-38-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,0 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91803-38:
(7*9)+(6*1)+(5*8)+(4*0)+(3*3)+(2*3)+(1*8)=132
132 % 10 = 2
So 91803-38-2 is a valid CAS Registry Number.

91803-38-2Downstream Products

91803-38-2Relevant articles and documents

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

Soares De Melo, Candice,Singh, Vinayak,Myrick, Alissa,Simelane, Sandile B.,Taylor, Dale,Brunschwig, Christel,Lawrence, Nina,Schnappinger, Dirk,Engelhart, Curtis A.,Kumar, Anuradha,Parish, Tanya,Su, Qin,Myers, Timothy G.,Boshoff, Helena I. M.,Barry, Clifton E.,Sirgel, Frederick A.,Van Helden, Paul D.,Buchanan, Kirsteen I.,Bayliss, Tracy,Green, Simon R.,Ray, Peter C.,Wyatt, Paul G.,Basarab, Gregory S.,Eyermann, Charles J.,Chibale, Kelly,Ghorpade, Sandeep R.

, p. 719 - 740 (2021/02/03)

Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb suggested a novel mechanism of action. The compounds were bactericidal against replicating Mtb and retained potency against clinical isolates of Mtb. Although selected MmpL3 mutant strains of Mtb showed resistance to these compounds, there was no shift in the minimum inhibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible resistance mechanism for the compounds but not necessarily as the target. RNA transcriptional profiling and the checkerboard board 2D-MIC assay in the presence of varying concentrations of ferrous salt indicated perturbation of the Fe-homeostasis by the compounds. Structure-activity relationship studies identified potent compounds with good physicochemical properties and in vitro microsomal metabolic stability with moderate selectivity over cytotoxicity against mammalian cell lines.

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