91806-21-2Relevant academic research and scientific papers
Hydrolysis kinetic studies of schiff bases derived from pyrrolic aldehydes in buffered aqueous ethanol and sulfuric acid solutions: Structural effects of substitutes
Bengharez, Zohra,El Bahri, Zineb,Mesli, Abderrezzak
, p. 404 - 414 (2013/07/05)
Two series of substituted N-pyrrolyl-2-methylene-aniline were synthesized and characterized to study their stability in a large domain of pH (0-14) and especially in the H0 domain (-4 to 0). The hydrolysis kinetics of the azomethine group was established in homogeneous media using a thermostated UV-vis spectrophotometer. The hydrolysis mechanism was investigated, and the experimental kinetic constants were calculated. Then, the pH-rate diagram profile was determined and the structural effect of substitutes on the kinetic constants was clarified and discussed.
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment
Kouznetsov, Vladímir V.,Vargas Méndez, Leonor Y.,Sortino, Maximiliano,Vásquez, Yelkaira,Gupta, Mahabir P.,Freile, Mónica,Enriz, Ricardo D.,Zacchino, Susana A.
, p. 794 - 809 (2008/09/17)
Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC = 3.12-6.25 μg/mL). In addition, all active compounds, 45-47, 73, and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents.
Novel Hydrolytic Cleavage of 4-(Pyrol-2-yl)azetidin-2-ones
Upadhyaya, Anil K.,Mehrotra, Kailash N.
, p. 957 - 960 (2007/10/02)
Alkaline hydrolysis of 1-aryl-3,3-diphenyl-4-(pyrol-2-yl)azetidin-2-ones results in an unusual dualpath fragmentation of the β-lactam ring to give diphenylacetic acid, 2-iminomethylpyrroles, arylamines, and 1,1-diphenyl-2-(pyrrol-2-yl)ethylene.The product distribution is shown to be dependent on temperature.
