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Upstream product

• 199444-49-0 3-Benzyl-5,6-dimethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione 
• 199444-38-7 5,6-Dimethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione 
• 26305-13-5 5,6-dimethyluracil 
• 138395-56-9 1,3-dibenzyl-5,6-dimethyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Direct N3 Alkylation of Uracil and Derivatives via N1-[2-(trimethylsilyl)ethoxymethyl] Protection

Protection at N1 position of uracil and uracil analogs as 2-(trimethylsilyl)ethoxymethyl derivatives permits the clean alkylation at N3. These protected uracils are quite stable in a wide range of pH.

A useful methodology for the regioselective deprotection of 1,3-dibenzyluracils

A practical, regioselective N-1 deprotection of 1,3-dibenzyl uracils 2 a-e is described. The same experimental procedure and longer reaction time afforded the complete deprotection of the uracils.