918133-14-9Relevant academic research and scientific papers
Sequence-specific nucleic acid damage induced by peptide nucleic acid conjugates that can be enzyme-activated
Simon, Philippe,Decout, Jean-Luc,Fontecave, Marc
, p. 6859 - 6861 (2007/10/03)
Recruitment drive: A 12 mer peptide nucleic acid(PNA)-flavin conjugate is prepared. When the PNA moiety is hybridized to its complementary sequence in a 25 mer oligo-2′-deoxyribonucleotide, the flavin moiety can recruit an NADPH:flavin oxidoreductase. This complex allows the activation of molecular oxygen in the presence of NADH and the selective oxidation of the oligonucleotide target (see scheme). (Figure Presented)
