91818-29-0

Basic information

• Product Name: 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE
• Synonyms: 2-cyano-N-(3-methoxyphenyl)ethanamide
• CAS NO: 91818-29-0
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 91818-29-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 427.7°C at 760 mmHg
• Flash Point: 212.4°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 1.61E-07mmHg at 25°C
• Refractive Index: 1.575
• PKA: -0.97±0.10(Predicted)
• CAS DataBase Reference: 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE(91818-29-0)
• EPA Substance Registry System: 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE(91818-29-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 91818-29-0(Hazardous Substances Data)

Usage

General Description

2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE is a chemical compound with the molecular formula C11H11N3O2. It is a cyanide derivative with a 3-methoxyphenyl group attached to the amide nitrogen. 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE has potential applications in the field of pharmaceuticals and organic synthesis due to its structural properties. It may be used as a starting material for the synthesis of various pharmaceutical drugs or as a building block for the development of new chemical compounds with potential biological activity. Additionally, it may also have industrial applications in the production of specialty chemicals. However, further research is needed to fully understand the potential uses and properties of 2-CYANO-N-(3-METHOXY-PHENYL)-ACETAMIDE.

InChI:InChI=1/C10H10N2O2/c1-14-9-4-2-3-8(7-9)12-10(13)5-6-11/h2-4,7H,5H2,1H3,(H,12,13)

Upstream product

• 536-90-3 m-Anisidine 
• 372-09-8 cyanoacetic acid 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 113604-11-8 (E)-2-Cyano-3-hydroxy-N-(3-methoxy-phenyl)-acrylamide 
• 128259-57-4 (E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide 
• 501037-54-3 N-(3-methoxy-phenyl)-2-thiocarbamoyl-acetamide 
• 1267972-63-3 C₁₅H₁₄N₂O₂ 
• 23058-90-4 N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide 
• 30034-43-6 7-methoxy-4-phenyl-1, 2-dihydroquinolin-2-one 

Relevant articles and documents

Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma

Development of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors is of great value and significance in the treatment of neoplastic disorders and inflammatory and autoimmune diseases. However, there is a lack of effective MALT1 inhibitors in clinic. Herein, a novel class of potent 5-oxo-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-based MALT1 inhibitors and their covalent derivatives were first identified and designed through high-throughput screening. We demonstrated that compounds 15c, 15e, and 20c effectively inhibited the MALT1 protease and displayed selective cytotoxicity to activated B cell-like diffuse large B cell lymphoma with low single-digit micromolar potency. Furthermore, compound 20c specifically repressed NF-κB signaling and induced cell apoptosis in MALT1-dependent TMD8 cells in a dose-dependent manner. More importantly, 20c showed good pharmacokinetic properties and antitumor efficacy with no significant toxicity in the TMD8 xenograft tumor model. Collectively, this study provides valuable lead compounds of MALT1 inhibitors for further structural optimization and antitumor mechanism study.

Synthesis of 2-cyano-3-dimethylamino-N-phenylacrylamides using the Vilsmeier reaction

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