91818-68-7 Usage
Uses
Used in Chemical Research:
4-Methyl-3-phenylisothiazol-5-amine is used as a research compound for its unique structural properties and potential applications in the development of new chemical entities or processes.
Used in Industrial Processes:
4-Methyl-3-phenylisothiazol-5-amine is used as an intermediate or catalyst in various industrial processes, leveraging its structural complexity and chemical characteristics to enhance or enable specific reactions or transformations.
Used in Pharmaceutical Development:
4-Methyl-3-phenylisothiazol-5-amine is used as a starting material or building block in the synthesis of pharmaceutical compounds, potentially contributing to the development of new drugs with novel therapeutic properties.
Used in Material Science:
4-Methyl-3-phenylisothiazol-5-amine is used in the development of new materials with specific properties, such as conductivity, stability, or reactivity, by incorporating its unique molecular structure into the material's composition.
Check Digit Verification of cas no
The CAS Registry Mumber 91818-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,1 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91818-68:
(7*9)+(6*1)+(5*8)+(4*1)+(3*8)+(2*6)+(1*8)=157
157 % 10 = 7
So 91818-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2S/c1-7-9(12-13-10(7)11)8-5-3-2-4-6-8/h2-6H,11H2,1H3
91818-68-7Relevant academic research and scientific papers
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
Fisher, Matthew J.,Backer, Ryan T.,Barth, Vanessa N.,Garbison, Kim E.,Gruber, Joseph M.,Heinz, Beverly A.,Iyengar, Smriti,Hollinshead, Sean P.,Kingston, Anne,Kuklish, Steven L.,Li, Linglin,Nisenbaum, Eric S.,Peters, Steven C.,Phebus, Lee,Simmons, Rosa Maria A.,Van Der Aar, Ellen
, p. 2514 - 2517 (2012/05/05)
The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2- methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy.
