918307-34-3Relevant academic research and scientific papers
Transition metal-catalyzed formation of CF3-substituted α,β-unsaturated alkene and the synthesis of α-trifluoromethyl substituted β-amino ester
Pang, Wan,Zhu, Shifa,jiang, Huanfeng,Zhu, Shizheng
, p. 11760 - 11765 (2006)
A new transition metal-catalyzed formation of CF3-substituted α,β-unsaturated alkenes through the ylide intermediate from the reaction between methyl 3,3,3-trifluoro-2-diazopropionate 1 and aryl aldehydes has been developed. Further transformation of the alkene affords the α-trifluoromethyl substituted β-amino ester, a valuable intermediate in the synthesis of fluorine-containing amino acids with potential biological application.
