918333-06-9Relevant academic research and scientific papers
3-Fluoro-Piperidine T-Type Calcium Channel Antagonists
-
Page/Page column 13, (2010/09/07)
The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels
Yang, Zhi-Qiang,Barrow, James C.,Snipe, William D.,Schlegel, Kelly-Ann S.,Shu, Youheng,Yang, F. Vivien,Lindsley, Craig W.,Rittle, Kenneth E.,Bock, Mark G.,Hartman, George D.,Uebele, Victor N.,Nuss, Cindy E.,Fox, Steve V.,Kraus, Richard L.,Doran, Scott M.,Connolly, Thomas M.,Tang, Cuyue,Ballard, Jeanine E.,Kuo, Yuhsin,Adarayan, Emily D.,Prueksaritanont, Thomayant,Zrada, Matthew M.,Marino, Michael J.,Graufelds, Valerie Kuzmick,DiLella, Anthony G.,Reynolds, Ian J.,Vargas, Hugo M.,Bunting, Patricia B.,Woltmann, Richard F.,Magee, Michael M.,Koblan, Kenneth S.,Renger, John J.
supporting information; experimental part, p. 6471 - 6477 (2009/10/23)
The discovery of a novel series of potent and selective T-type calcium channel antagonists is reported. Initial optimization of high-throughput screening leads afforded a 1,4-substituted piperidine amide 6 with good potency and limited selectivity over hE
3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS
-
Page/Page column 27, (2008/06/13)
The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel
