918409-08-2Relevant academic research and scientific papers
EP300/CREBBP INHIBITOR
-
, (2020/05/30)
The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.
(2R)- and (2S)-3-fluoroalanine and their N-methyl derivatives: Synthesis and incorporation in peptide scaffolds
Hoveyda, Hamid R.,Pinault, Jean-Francois
, p. 5849 - 5852 (2007/10/03)
(Diagram presented) A convergent synthetic methodology has been developed to access both (2S)- and (2R)-3-fluoroalanine and their corresponding N-methyl analogues, in optically pure form, through a common oxazolidinone intermediate that can be obtained fr
