918422-35-2Relevant academic research and scientific papers
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists
Li, An-Rong,Johnson, Michael G.,Liu, Jiwen,Chen, Xiaoqi,Du, Xiaohui,Mihalic, Jeffrey T.,Deignan, Jeffrey,Gustin, Darin J.,Duquette, Jason,Fu, Zice,Zhu, Liusheng,Marcus, Andrew P.,Bergeron, Phillipe,McGee, Lawrence R.,Danao, Jay,Lemon, Bryan,Carabeo, Teresa,Sullivan, Timothy,Ma, Ji,Tang, Liang,Tonn, George,Collins, Tassie L.,Medina, Julio C.
, p. 688 - 693 (2008/09/18)
A series of six-six and six-five fused heterocyclic CXCR3 antagonists has been synthesized and their activities evaluated in an [125I]-IP-10 displacement assay and an ITAC mediated in vitro cell migration assay. The pharmacokinetic properties o
ARYL NITRILE COMPOUNDS AND COMPOSITIONS AND THEIR USES IN TREATING INFLAMMATORY AND RELATED DISORDERS
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Page/Page column 56, (2010/11/25)
Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a ch
