918441-54-0Relevant academic research and scientific papers
Asymmetric Hydrogenation of Ketones and Enones with Chiral Lewis Base Derived Frustrated Lewis Pairs
Du, Haifeng,Feng, Xiangqing,Gao, Bochao,Meng, Wei
supporting information, p. 4498 - 4504 (2020/02/05)
The concept of frustrated Lewis pairs (FLPs) has been widely applied in various research areas, and metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In the past decade, great efforts have been devoted to the synthesis of chiral boron Lewis acids. In a sharp contrast, chiral Lewis base derived FLPs have rarely been disclosed for the asymmetric hydrogenation. In this work, a novel type of chiral FLP was developed by simple combination of chiral oxazoline Lewis bases with achiral boron Lewis acids, thus providing a promising new direction for the development of chiral FLPs in the future. These chiral FLPs proved to be highly effective for the asymmetric hydrogenation of ketones, enones, and chromones, giving the corresponding products in high yields with up to 95 % ee. Mechanistic studies suggest that the hydrogen transfer to simple ketones likely proceeds in a concerted manner.
ANTIMICROBIAL COMPOUNDS AND METHODS
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Paragraph 00775, (2020/07/31)
The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
Synthesis and properties of α,ω-phenyl-capped bithiophene derivatives
Janssen, Pim G.A.,Pouderoijen, Maarten,Van Breemen, Albert J.J.M.,Herwig, Peter T.,Koeckelberghs, Guy,Popa-Merticaru, Andreea R.,Meskers, Stefan C.J.,Valeton, Josue J.P.,Meijer,Schenning, Albertus P.H.J.
, p. 4335 - 4342 (2007/10/03)
Nine different α,ω-phenyl-endcapped bithiophenes were synthesised, and the effect of the different side chains on the liquid crystalline properties, alignment ability and charge carrier mobility have been studied. An increase in chain length leads to a de
