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Usage

Uses

Used in Pharmaceutical Applications:
6-Isoquinolinol, 5-chlorois used as a building block for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs.
Used in Antimicrobial Applications:
6-Isoquinolinol, 5-chlorois used as an antimicrobial agent due to its potential to inhibit the growth of certain microorganisms. This property makes it a promising candidate for drug development in the treatment of bacterial infections.
Used in Antifungal Applications:
6-Isoquinolinol, 5-chlorois used as an antifungal agent, showing potential to combat fungal infections. Its effectiveness in this area could lead to the development of new antifungal medications.
Used in Industrial Applications:
6-Isoquinolinol, 5-chloromay also find use in various industrial applications, such as the synthesis of dyes, pigments, and other specialty chemicals, owing to its unique chemical properties.

Upstream product

• 7651-82-3 isoquinolin-6-ol 

Relevant academic research and scientific papers

RadH: A Versatile Halogenase for Integration into Synthetic Pathways

Flavin-dependent halogenases are useful enzymes for providing halogenated molecules with improved biological activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromatic scaffolds. Site-directed mutagenesis of RadH was used to identify catalytic residues and provide insight into the mechanism of fungal halogenases. A high-throughput fluorescence screen was also developed, which enabled a RadH mutant to be evolved with improved properties. Finally we demonstrate how biosynthetic genes from fungi, bacteria, and plants can be combined to encode a new pathway to generate a novel chlorinated coumarin “non-natural” product in E. coli.

Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase

Rdc2 is the first flavin-dependent halogenase identified from fungi. Based on the reported structure of the bacterial halogenase CmlS, we have built a homology model for Rdc2. The model suggests an open substrate binding site that is capable of binding the natural substrate, monocillin II, and possibly other molecules such as 4-hydroxyisoquinoline (1) and 6-hydroxyisoquinoline (2). In vitro and in vivo halogenation experiments confirmed that 1 and 2 can be halogenated at the position ortho to the hydroxyl group, leading to the synthesis of the chlorinated isoquinolines 1a and 2a, respectively, which further expands the spectrum of identified substrates of Rdc2. This work revealed that Rdc2 is a useful biocatalyst for the synthesis of various halogenated compounds.

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES

The invention relates to 6-substituted isoquinoline derivatives of the Formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE

The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I); useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.