918504-27-5

Basic information

• Product Name: 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
• Synonyms: 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-;N-(3-(5-broMo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
• CAS NO: 918504-27-5
• Molecular Formula: C₁₇H₁₄BrF₂N₃O₃S
• Molecular Weight: 458.2771664
• Mol File: 918504-27-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 634.243 °C at 760 mmHg
• Flash Point: 337.378 °C
• Appearance: /
• Density: 1.689 g/cm³
• Storage Temp.: 2-8°C
• PKA: 6.19±0.10(Predicted)
• CAS DataBase Reference: 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-(918504-27-5)
• EPA Substance Registry System: 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-(918504-27-5)

Safety Data

• Hazardous Substances Data: 918504-27-5(Hazardous Substances Data)

Usage

General Description

1-Propanesulfonamide, N-[3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- is a chemical compound with a complex and specific structure. It contains a propanesulfonamide group along with a substituted pyrrolopyridine ring. 1-Propanesulfonamide, N-[3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- also consists of a bromo group, a carbonyl group, and two fluorine atoms attached to a phenyl ring. The chemical is likely to have unique properties and potential applications, but its exact uses and characteristics would require further investigation and research.

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 918523-45-2 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 
• 918523-44-1 3-amino-2,6-difluoro-benzoic acid benzyl ester 
• 918521-11-6 [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-carbamic acid methyl ester 
• 1312941-97-1 {3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-carbamic acid methyl ester 
• 1309431-01-3 methyl N-(2,4-difluoro-3-formyl-phenyl)carbamate 
• 10147-36-1 n-propanesulfonyl chloride 
• 1312941-98-2 (3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 1186194-32-0 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride 
• 1186223-50-6 methyl 2,6-difluoro-3-(propylsulfonamido)benzoate 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 260552-98-5 2,6-difluoro-3-nitrobenzoic acid chloride 

Downstream Products

• 1244037-16-8 propane-1-sulfonic acid {2,4-difluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenylamide} 
• 1312940-03-6 4-(4-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1312940-04-7 propane-1-sulfonic acid {2,4-difluoro-3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide 
• 1312939-63-1 propane-1-sulfonic acid {2,4-difluoro-3-[5-(1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide 
• 1312939-79-9 propane-1-sulfonic acid {3-[1-(2,6-dichloro-benzoyl)-5-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide 
• 1312939-69-7 propane-1-sulfonic acid {3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide 
• 1312939-78-8 propane-1-sulfonic acid {2,4-difluoro-3-[5-(1-methanesulfonyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide 
• 1262985-23-8 propane-1-sulfonic acid {3-[5-(4-chlorophenyl) 1-(2,6-dichloro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide 
• 1029872-54-5 vemurafenib 
• 1415041-85-8 propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt 

Relevant articles and documents

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The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.