91853-46-2

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxois used as a reagent in the synthesis of endopeptidase inhibitors for the pharmaceutical industry. Endopeptidase inhibitors are important therapeutic agents that can modulate the activity of enzymes involved in various biological processes, such as blood clotting, inflammation, and immune responses. The unique structure of [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo- allows it to be a valuable building block in the development of novel endopeptidase inhibitors with improved potency, selectivity, and pharmacokinetic properties.

Upstream product

• 66404-26-0 2-Phenyl-4-(4-phenylbenzylidene)oxazol-5-one 
• 3218-36-8 4-Phenylbenzaldehyde 
• 461-72-3 2,4-imidazolidinedione 
• 1188995-14-3 (Z)-4-([1,10-biphenyl]-4-ylmethylene)-2-methyloxazol-5(4H)-one 
• 1057002-37-5 4-[1-biphenyl-4-yl-meth-(Z)-ylidene]-2-phenyl-4H-oxazol-5-one 
• 1667-11-4 biphenyl-4-methylchloride 

Downstream Products

• 170080-13-4 ([1,1’-biphenyl]-4-yl)alanine 
• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 128779-47-5 (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 
• 1426129-50-1 N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester 
• 100474-22-4 3-(3-Biphenyl-4-yl-4-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-propionic acid ethyl ester 
• 100474-65-5 3-(3-Biphenyl-4-yl-4-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-propionic acid 

Relevant academic research and scientific papers

Preparation method of Sacubitril key intermediate

The invention discloses a synthesis and preparation method of Sacubitril key intermediate N-[(1R)-2-(1,1'-biphenyl)-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester. The preparation method comprises the steps of adopting 4-biphenylcarboxaldehyde and hydantoin as starting materials; carrying out condensation and hydrolysis 'one-pot method' reaction, esterification reaction, dissymmetricaltransamination reaction, and Boc protection and reduction reaction to synthesize and prepare the target product. The preparation method has the characteristics of easiness in obtaining the reaction raw materials, short path, high reaction stereoselectivity, mild conditions, simple and convenient process operation, and the like, and is suitable for industrial production.

NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

SUBSTITUTED DIPEPTIDES AS INHIBITORS OF ENKEPHALINASES

A method for inhibiting the action of enkephalinases in a mammal to thereby elicit an analgesic effect in said mammal is described. Novel compound and compositions useful for accomplishing the method of the invention are also described.

SUBSTITUTED DIPEPTIDES AS INHIBITORS OF ENKEPHALINASES

A method for inhibiting the action of enkephalinases in a mammal to thereby elicit an analgesic effect in said mammal is described. Novel compounds and compositions useful for accomplishing the method of the invention are also described.