91853-46-2

Basic information

• Product Name: [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo-
• Synonyms: [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo-;4-Biphenylylpyruvic Acid
• CAS NO: 91853-46-2
• Molecular Formula: C15H12O3
• Molecular Weight: 240.25398
• Mol File: 91853-46-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo-(91853-46-2)
• EPA Substance Registry System: [1,1'-Biphenyl]-4-propanoic acid, .alpha.-oxo-(91853-46-2)

Safety Data

• Hazardous Substances Data: 91853-46-2(Hazardous Substances Data)

Usage

Uses

4-Biphenylylpyruvic Acid is a derivative of 4-Biphenylylcarboxaldehyde (B397845) and is used as a reagent in the synthesis of endopeptidase inhibitors.

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 3218-36-8 4-Phenylbenzaldehyde 
• 1188995-14-3 (Z)-4-([1,10-biphenyl]-4-ylmethylene)-2-methyloxazol-5(4H)-one 
• 1057002-37-5 4-[1-biphenyl-4-yl-meth-(Z)-ylidene]-2-phenyl-4H-oxazol-5-one 
• 1667-11-4 biphenyl-4-methylchloride 
• 66404-26-0 2-Phenyl-4-(4-phenylbenzylidene)oxazol-5-one 

Downstream Products

• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 128779-47-5 (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 
• 1426129-50-1 N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester 
• 170080-13-4 ([1,1’-biphenyl]-4-yl)alanine 
• 100474-22-4 3-(3-Biphenyl-4-yl-4-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-propionic acid ethyl ester 
• 100474-65-5 3-(3-Biphenyl-4-yl-4-hydroxy-5-oxo-2,5-dihydro-furan-2-yl)-propionic acid 

Relevant articles and documents

Preparation method of Sacubitril key intermediate

The invention discloses a synthesis and preparation method of Sacubitril key intermediate N-[(1R)-2-(1,1'-biphenyl)-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester. The preparation method comprises the steps of adopting 4-biphenylcarboxaldehyde and hydantoin as starting materials; carrying out condensation and hydrolysis 'one-pot method' reaction, esterification reaction, dissymmetricaltransamination reaction, and Boc protection and reduction reaction to synthesize and prepare the target product. The preparation method has the characteristics of easiness in obtaining the reaction raw materials, short path, high reaction stereoselectivity, mild conditions, simple and convenient process operation, and the like, and is suitable for industrial production.

SUBSTITUTED DIPEPTIDES AS INHIBITORS OF ENKEPHALINASES

A method for inhibiting the action of enkephalinases in a mammal to thereby elicit an analgesic effect in said mammal is described. Novel compound and compositions useful for accomplishing the method of the invention are also described.