918540-63-3Relevant academic research and scientific papers
Enantioselective Reduction of α,β-Unsaturated Ketones and Aryl Ketones by Perakine Reductase
Cai, Sheng,Shao, Nana,Chen, Yuanyuan,Li, Anbang,Pan, Jie,Zhu, Huajian,Zou, Hongbin,Zeng, Su,Sun, Lianli,Zhao, Jinhao
, p. 4411 - 4414 (2019/05/22)
This report describes the enantioselective reduction of structurally diverse α,β-unsaturated ketones and aryl ketones by perakine reductase (PR) from Rauvolfia. This enzymatic reduction produces α-chiral allylic and aryl alcohols with excellent enantioselectivity and most of the products in satisfactory yields. Furthermore, the work demonstrates 1 mmol scale reactions for product delivery without any detrimental effect on yield and enantioselectivity. The catalytic mechanism, determined by 3D-structure-based modeling of PR and ligand complexes, is also described.
Gas-phase pyrolytic reaction of 4-Aryl-3-buten-2-ols and allyl benzyl ethers: Kinetic and mechanistic study
Al-Etaibi, Alya M.,Al-Awadi, Nouria A.,Ibrahim, Maher R.,Ibrahim, Yehia A.
experimental part, p. 407 - 419 (2010/05/02)
Flash vacuum pyrolysis (FVP) of 4-aryl-3-buten-2-ols [ArCH=CHCH(CHs)OH, where Ar is phenyl, p-MeO, p-Me, p-Cl, p-NO2] gave the corresponding buta-1,3-dien-1-ylbenzene (ArCH=CH-CH=CH2, where Ar is Ph, p-MeO, p-Me, p-Cl, pNO2) and 7-×-1,2-dihydronaphthalene derivatives (where X is H, MeO); FVP of 1-aryl-3benzyloxyl-1-butenes and benzyl cinnamyl ethers [ArCH=CHCH(X)OCH2Ph, where Ar is phenyl, p-MeO, p-Me, p-Cl, X is H, Me, Ph] gave the corresponding but-2-en-l-ylbenzene derivatives (ArCH 2CH=CH-X, where X is H, Me, Ph) together with benzaldehyde. The proposed mechanism of these pyrolytic transformations was supported by kinetic and product analysis.
