918540-97-3Relevant academic research and scientific papers
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors
Zhou, Ping,Li, Yanfang,Fan, Yi,Wang, Zheng,Chopra, Rajiv,Olland, Andrea,Hu, Yun,Magolda, Ronald L.,Pangalos, Menelas,Reinhart, Peter H.,Turner, M. James,Bard, Jonathan,Malamas, Michael S.,Robichaud, Albert J.
scheme or table, p. 2326 - 2329 (2010/08/22)
A novel class of pyridinyl aminohydantoins was designed and prepared as highly potent BACE1 inhibitors. Compound (S)-4g showed excellent potency with IC50 of 20 nM for BACE1. X-ray crystallography indicated that the interaction between pyridine
