91869-09-9

Upstream product

• 1145-15-9 5-(3,4-dimethoxyphenyl)pentanoic acid 
• 101619-71-0 (2E,4E)-ethyl 5-(3,4-dimethoxyphenyl)penta-2,4-dienoate 
• 874518-45-3 5-(3,4-dimethoxyphenyl)pentanoic acid ethyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 91887-06-8 1-<5-(3,4-Dimethoxyphenyl)-1-oxopentyl>piperidin 
• 91887-07-9 1-<5-(3,4-Dimethoxyphenyl)-1-oxopentyl>-4-hydroxypiperidin 
• 77775-67-8 5-(3,4-dimethoxyphenyl)valeramide 
• 436155-60-1 methyl 2-[5-(3,4-dimethoxyphenyl)pentanoyl]hydrazinecarboxylate 
• 1452406-10-8 6-(3,4-dimethoxyphenyl)-1,1,1-trifluorohexan-2-one 
• 1452406-19-7 7-(3,4-dimethoxyphenyl)-1,1,1,2,2-pentafluoroheptan-3-one 
• 64648-01-7 N-Chloroacetyl-5-(3,4-dimethoxyphenyl)pentylamine 
• 91869-10-2 1-<5-<3,4-Bis(trimethylsilyloxy)phenyl>-1-oxopentyl>-4-trimethylsilyloxypiperidin 
• 91869-11-3 5-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-piperidin-1-yl)-pentan-1-one 

Relevant academic research and scientific papers

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

Group VIA calcium-independent phospholipase A2 (GVIA iPLA 2) has recently emerged as an important pharmaceutical target. Selective and potent GVIA iPLA2 inhibitors can be used to study its role in various neurological diso

Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles

Appropriate aryl-substituted unsymmetrical azodicarbonyl compounds, generated from bishydrazides by oxidation, undergo intramolecular cyclisations to furnish a variety of useful heterocycles such as N-substituted oxindoles, carbostyrils, benzazepinones, benzazocinones, benzimidazolones, benzoxazinones and pyrazolones in varying degrees of efficiency. Methods are described to remove the N-acyl groups from the heteroaromatic compounds. Under mildly acidic conditions where equal opportunities are available for an ipso or a normal cyclisation it is the former process that occurs preferentially. Evidence is presented in favour of a C-to-C migration in the ipso product for the formation of a methoxy-substituted carbostyril derivative. One of the spiro substances is shown to participate in dienone-phenol rearrangement to provide the corresponding quinolone-phenol in high yield.

Piperine - an Example of Individually Different (Polymorph) Metabolism of an Omnipresent Nutrition Component

Searching for the origin of components disturbing human urinary steroid profiles, two previously unknown compounds were detected: 5-(3,4-dihydroxyphenyl)valeric acid piperidide (17) and its in position 4 of the piperidine ring hydroxylated derivative 18.I