91872-12-7

Upstream product

• 5382-44-5 quinoline-2-carboxylic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 634169-20-3 C₁₇H₁₂N₄S 
• 91872-14-9 C₁₇H₁₂N₄O 
• 1125771-91-6 C₁₇H₁₂N₄S 
• 1125771-79-0 C₁₉H₁₄N₄O₂S 
• 1125771-87-0 C₂₀H₁₆N₄OS 
• 1125771-83-6 C₂₀H₁₆N₄O₂S 

Relevant academic research and scientific papers

Synthesis and reactions of some new quinoline thiosemicarbazide derivatives of potential biological activity

Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a-e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)-2H-1, 2, 4-triazole-3(4H)-thiones (5a-e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol- 2-amines (6a-e). Treatment of thiosemicarbazides with ethyl bromoacetate or α -bromopropionic acid yielded (Z)-N′-(3-substituted thiazolidin-4-oxo-2-ylidene) quinoline-2-carbohydrazides (7a-d), (8a-d), respectively. Treatment of thiosemicarbazides with chloroacetone furnished (Z)-N′-(4-methyl-3- substituted-thiazol-2(3H)-ylidene) quinoline-2-carbohydrazides (9a-d). Furthermore, the reaction of thiosemicarbazides with phosphorus oxychloride gave N-substituted-5-(quinolin-2-yl)-1,3,4-thiadiazol-2-amines (10a-e). All newly synthesized compounds were tested and evaluated for antimicrobial activity. Copyright Taylor & Francis Group, LLC.