91874-85-0 Usage
Uses
(2,3-Dimethylphenyl)-1H-imidazol-5-ylmethanone was used for tandem addition reduction to synthesize 4(5)?-?[1-?(2,?3-?dimethylphenyl)?-?1H-?imidazole, the α2-?adrenergic agonist medetomidine.
Check Digit Verification of cas no
The CAS Registry Mumber 91874-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,7 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 91874-85:
(7*9)+(6*1)+(5*8)+(4*7)+(3*4)+(2*8)+(1*5)=170
170 % 10 = 0
So 91874-85-0 is a valid CAS Registry Number.
91874-85-0Relevant articles and documents
Expedient synthesis of 4(5)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, the α2-adrenergic agonist medetomidine
Kudzma,Turnbull Jr.
, p. 1021 - 1022 (2007/10/02)
(+)-4(5)-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (5) is prepared in three steps in 79% overall yield from 1-(N,N-dimethylsulfamoyl)imidazole by bis-protection, regioselective lithiation followed by an efficient tandem addition-reduction of the resulting 2,3-dimethylbenzoyl chloride adduct with lithium/ammonia/ammonium chloride.