91874-85-0

Basic information

• Product Name: Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry
• Synonyms: Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry;(2,3-diMethylphenyl)(1H-iMidazol-4-yl)Methanone;4-(2',3'-DiMethylbenzoyl)iMidazole;Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl-
• CAS NO: 91874-85-0
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol File: 91874-85-0.mol

Chemical Properties

• Boiling Point: 412.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.30±0.10(Predicted)
• CAS DataBase Reference: Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry(91874-85-0)
• EPA Substance Registry System: Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry(91874-85-0)

Safety Data

• Hazardous Substances Data: 91874-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-ylchemistry is used as a key intermediate in the synthesis of various pharmaceutical compounds. One notable example is its application in the synthesis of the α2-adrenergic agonist medetomidine, which is an important drug used in veterinary medicine for sedation, analgesia, and anesthesia.
In the synthesis process, (2,3-dimethylphenyl)-1H-imidazol-5-ylmethanone undergoes a tandem addition-reduction reaction to form the desired 4(5)-[1-(2,3-dimethylphenyl)-1H-imidazole] compound. This reaction showcases the versatility and utility of Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-ylchemistry in the development of pharmaceutical agents.
While the provided materials do not explicitly mention other industries or applications, the unique structure and properties of Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-ylchemistry suggest that it may have potential uses in other fields, such as materials science, agrochemicals, or as a research tool in chemical biology. Further exploration and research would be necessary to identify and validate these potential applications.

Upstream product

• 21900-46-9 2,3-dimethylbenzoyl chloride 
• 138867-04-6 1-N,N-Dimethylsulfamoyl-2-(tert-butyldimethylsilyl)-5-(2,3-dimethylbenzoyl)imidazole 

Downstream Products

• 86347-14-0 (+/-)-4(5)-<1-(2,3-Dimethylphenyl)ethyl-1H-imidazole> 

Relevant articles and documents

Expedient synthesis of 4(5)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, the α2-adrenergic agonist medetomidine

(+)-4(5)-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (5) is prepared in three steps in 79% overall yield from 1-(N,N-dimethylsulfamoyl)imidazole by bis-protection, regioselective lithiation followed by an efficient tandem addition-reduction of the resulting 2,3-dimethylbenzoyl chloride adduct with lithium/ammonia/ammonium chloride.