918797-38-3Relevant academic research and scientific papers
Discovery of oxybisbenzoylamides as a new class of antimalarial agents
Pancotti,Parapini,Dell'Agli,Gambini,Galli,Sangiovanni,Basilico,Bosisio,Taramelli,Romeo
, p. 1173 - 1177 (2015/06/25)
We have previously described several potent dual inhibitors of Plasmodium falciparum (Pf) growth characterized by the presence of statine, a β-hydroxyl amino acid able to inhibit parasite's plasmepsins (PLMs). While investigating the mechanism of action o
High antiplasmodial activity of novel plasmepsins I and II inhibitors
Dell'Agli, Mario,Parapini, Silvia,Galli, Germana,Vaiana, Nadia,Taramelli, Donatella,Sparatore, Anna,Liu, Peng,Dunn, Ben M.,Bosisio, Enrica,Romeo, Sergio
, p. 7440 - 7449 (2007/10/03)
The aim of this study was to develop new antiplasmodial compounds acting through distinct mechanisms during both the liver and the blood stages of the parasite life cycle. Compounds were designed on the basis of the "double-drug" approach: primaquine, whi
