918822-80-7Relevant academic research and scientific papers
A cleavable amino-thiol linker for reversible linking of amines to DNA
Hojfeldt, Jonas W.,Blakskjaer, Peter,Gothelf, Kurt V.
, p. 9556 - 9559 (2007/10/03)
(Chemical Equation Presented) A cleavable heterobifunctional cross-linker for the reversible conjugation of amines to thiol-modified DNA has been developed and tested. The succinimidyl 2-(vinylsulfonyl)-ethyl carbonate (SVEC) was prepared in three steps and tested for its ability to react with amines and thiols. The linker was efficient for binding leucine to a thiol-modified DNA sequence and for releasing the amino acid at pH 11.8.
