918868-33-4Relevant academic research and scientific papers
Synthesis of migrastatin and its macrolide core
Reymond, Sébastien,Cossy, Janine
, p. 5918 - 5929 (2008/02/02)
Migrastatin and its macrolactone subunit are potent antimetastatic agents. Both were synthesized by using a ring-closing metathesis (RCM) to establish the macrolactone core, and the control of the (Z)-trisubstituted double bond at C11-C12 was achieved by?
Total synthesis of (+)-migrastatin
Reymond, Sebastien,Cossy, Janine
, p. 4800 - 4804 (2007/10/03)
(+)-Migrastatin, an antimetastatic agent, was synthesized by using three ruthenium-catalyzed metathesis reactions: a ring-closing metathesis (RCM) to control the (Z)-trisubstituted double bond at C11-C12, another RCM at C6-C7 to establish the macrolactone
