918870-24-3Relevant academic research and scientific papers
2-ARYLAMINO PYRIDINE, PYRIDINE OR TRIAZINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
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Paragraph 0050; 0051; 0052, (2018/07/29)
The present disclosure relates to 2-arylamino pyridine, pyrimidine, or triazine derivatives, and the preparation method and use thereof. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may act on certain mutated forms of epidermal growth fac
EGFR INHIBITOR COMPOUNDS
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Paragraph 0168, (2017/12/29)
Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF
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Paragraph 0106; 0629; 0630, (2017/09/02)
A 4-substituted-2-(N-(5-substituted allyl amide)phenyl)amino)pyrimidine derivative as represented by formula (I), and a preparation and application thereof as an EGFR inhibitor. The compound has activity of inhibiting the L858R EGFR mutant, the T790M EGFR mutant and the exon 19 deletion activating mutant, may be used to treat diseases mediated alone or in part by EGFR mutant activity, and has a wide application in drugs preventing and treating cancers, particularly non-small cell lung cancer.
JNK modulators
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Page/Page column 93, (2008/12/06)
Compounds of formula I modulate JNK: wherein the variables are as defined herein.
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)
Sabat, Mark,VanRens, John C.,Laufersweiler, Matthew J.,Brugel, Todd A.,Maier, Jennifer,Golebiowski, Adam,De, Biswanath,Easwaran, Vijayasurian,Hsieh, Lily C.,Walter, Richard L.,Mekel, Marlene J.,Evdokimov, Artem,Janusz, Michael J.
, p. 5973 - 5977 (2007/10/03)
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representat
