918884-77-2Relevant academic research and scientific papers
A novel synthesis of 5-substituted isoxazoles from propargylic amines and N-hydroxyphthalimide
Zhang, Yicheng,Chen, Wei,Jia, Xueshun
supporting information, p. 2181 - 2183 (2018/05/08)
A mild and efficient method for the synthesis of 5-substituted isoxazoles through cyclization of propargylic amines with N-hydroxyphthalimide (NHPI) under metal-free conditions was developed.
TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3
He, Yan,Xie, Yu-Yang,Wang, Ying-Chun,Bin, Xiao-Min,Hu, Da-Chao,Wang, Heng-Shan,Pan, Ying-Ming
, p. 58988 - 58993 (2016/07/06)
A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3via a radical mechanism process is described. This methodology provides an easy access to a variety of useful 5-substituted isoxazoles
Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands
Swain, Christopher J.,Teran, Ana,Maroto, Marta,Cabello, Angeles
, p. 6058 - 6062 (2007/10/03)
A several series of low molecular weight 5-HT2A leads were identified from an analysis of HTS data, the exploration of SAR and optimization of one series using parallel synthesis are described, affording compound 22 (5-HT2A IC50 1.1 nM).
