91889-35-9 Usage
Uses
Used in Organic Synthesis:
4'-Methoxypropiophenone-d2 is used as a synthetic intermediate for the preparation of various organic compounds. Its deuterated nature provides unique advantages in certain chemical reactions, such as improved reaction rates, enhanced selectivity, and reduced side reactions. This makes it a valuable tool in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Deuterium Labeling:
In the field of chemical research, 4'-Methoxypropiophenone-d2 is employed as a deuterium-labeled compound for studying reaction mechanisms and kinetics. The incorporation of deuterium atoms allows for the differentiation between isotopologues, providing insights into the reaction pathways and helping to elucidate the underlying chemistry.
Used in Analytical Chemistry:
4'-Methoxypropiophenone-d2 can be utilized as an internal standard in analytical chemistry for the accurate quantification of related compounds. Its distinct mass and chemical properties enable precise measurements and improve the reliability of analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4'-Methoxypropiophenone-d2 serves as a key building block for the synthesis of deuterated drug candidates. The introduction of deuterium into the molecular structure can potentially enhance the stability, bioavailability, and metabolic profile of the resulting drug molecules, leading to improved therapeutic efficacy and reduced side effects.
Used in Material Science:
4'-Methoxypropiophenone-d2 also finds applications in the field of material science, where it is used to synthesize deuterated polymers and other advanced materials. These materials exhibit unique properties, such as enhanced thermal stability, improved mechanical strength, and altered electronic behavior, which can be exploited in various high-performance applications.
Check Digit Verification of cas no
The CAS Registry Mumber 91889-35-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,8,8 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 91889-35:
(7*9)+(6*1)+(5*8)+(4*8)+(3*9)+(2*3)+(1*5)=179
179 % 10 = 9
So 91889-35-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O2/c1-3-10(11)8-4-6-9(12-2)7-5-8/h4-7H,3H2,1-2H3/i3D2
91889-35-9Relevant academic research and scientific papers
Modular Ni(0)/Silane Catalytic System for the Isomerization of Alkenes
Chang, Alison Sy-Min,Cook, Amanda K.,Kawamura, Kiana E.,Martin, Daryl J.,Morris, Parker T.,Smith, Haley M.
supporting information, p. 486 - 496 (2022/03/02)
Alkenes are used ubiquitously as starting materials and synthetic targets in all areas of chemistry. Controlling their geometry and position along a chain is vital to their reactivity and properties yet remains challenging. Alkene isomerization is an atom-economical process to synthesize targeted alkenes, and selectivity can be controlled using transition metal catalysts. The development of mild, selective isomerization reactivity has enabled efficient tandem catalytic systems for the remote functionalization of alkenes, a process in which a starting alkene is isomerized to a new position prior to the functionalization step. The key challenges in developing isomerization catalysts for remote functionalization applications are (i) a lack of modularity in the catalyst structure and (ii) the requirement of nonmodular and/or harsh additives during catalyst activation. We address both challenges with a modular (NHC)Ni(0)/silane catalytic system (NHC, N-heterocyclic carbene), demonstrating the use of triaryl silanes and readily accessible (NHC)Ni(0) complexes to form the proposed active (NHC)(silyl)Ni-H species in situ. We show that modification of the steric and electronic nature of the catalyst via modification of the ancillary ligand and silane partner, respectively, is easily achieved, creating a uniquely versatile catalytic system that is effective for the formation of internal alkenes with high yield and selectivity for the E-alkene. The use of silanes as mild activators enables isomerization of substrates with a variety of functional groups, including acid-labile groups. The broad substrate scope, enabled by catalyst design, makes this catalytic system a strong candidate for use in tandem catalytic applications. Preliminary mechanistic studies support a Ni-H insertion/elimination pathway.
