91890-06-1Relevant academic research and scientific papers
Rhodium(I)- or ruthenium(II)-catalyzed direct coupling of vinyl ketones with aldehydes and the subsequent reduction to give aldol derivatives anti-selectively
Sato, Susumu,Matsuda, Isamu,Shibata, Masahiro
, p. 347 - 356 (2007/10/02)
A vinyl ketone reacts with an aldehyde to give an α-methylene-β-hydroxyalkanone with the concomitant formation of the vinyl ketone dimer in the presence of catalytic amount of RhH(PPh3)4 or RuH2(PPh3)4 under almost neutral conditions.The selectivity of th
Stereoselective Syntheses of Alkohols, XXV. - Generation of Enol Borates and Their Addition to Aldehydes
Hoffmann, Reinhard W.,Ditrich, Klaus,Froech, Sybille
, p. 977 - 986 (2007/10/02)
Ketone-derived enol borates, especially those having a 4,4,5,5-tetramethyl-1,3,2-dioxaborolane unit, are stable compounds,which have been prepared either by borylation of lithium enolates or by oxidation of vinylboronates.These E- or Z-enol borates add to aldehydes in a stereoconvergent reaction leading to syn-aldols.Aldehyde-derived enol borates have a high tendency towards polymerization.Their in-situ addition to aldehydes generates 4-alkoxy-1,3,2-dioxaborinanes, which are internally protected aldols.
SYN-SELECTIVE ADDITION OF ENOL BORATES TO ALDEHYDES
Hoffmann, Reinhard W.,Ditrich, Klaus
, p. 1781 - 1784 (2007/10/02)
Both the Z- and the E-enolborate 4 and 6 add to aldehydes in a stereoconvergent reaction to give β-hydroxyketones with a syn/anti ratio of >= 9 : 1.
Stereo- and Regio-controlled Aldol Synthesis using Relative 1,2-Asymmetric Induction
Sato, Fumie,Takeda, Yoshiyuki,Uchiyama, Hiroshi,Kobayashi, Yuichi
, p. 1132 - 1134 (2007/10/02)
Highly stereoselective addition of nucleophiles to α-methyl-β-methylene carbonyl compounds combined with the hydromagnesiation reactions of 2-alkyl-substituted 1,3-dienes affords a practical, efficient stereo- and regio-controlled aldol synthesis.
