918903-20-5

Basic information

• Product Name: Carvedilol Bis-carbazole
• Synonyms: 1,1'-[[2-(2-Methoxyphenoxy)ethyl]imino]bis[3-(9H-carbazol-4-yloxy)-2-propanol;Carvedilol Bis-carbazole;Carvedilol Related Compound B;Carvedilol Related Compound B (15 mg) (3,3'-(2-(2-methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol));Carvedilol IMpurity-B(EP);Carvedilol EP IMpurity B;Carvedilol impurity B (PhEur);Carvedilol Related Compound B (USP)
• CAS NO: 918903-20-5
• Molecular Formula: C₃₉H₃₉N₃O₆
• Molecular Weight: 643.72758
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles;Impurities
• Mol File: 918903-20-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 905.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.328±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Very Slight
• PKA: 13.53±0.20(Predicted)
• BRN: 14441019
• CAS DataBase Reference: Carvedilol Bis-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: Carvedilol Bis-carbazole(918903-20-5)
• EPA Substance Registry System: Carvedilol Bis-carbazole(918903-20-5)

Safety Data

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 918903-20-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 918903-20-5 differently. You can refer to the following data:
1. An impurity from the process of Carvedilol. Carvedilol impurity B
2. An impurity from the process of Carvedilol (C184625). Carvedilol impurity B.
3. Carvedilol Bis-carbazole (Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B) is an impurity from the process of Carvedilol (C184625).

Upstream product

• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 
• 69-72-7 salicylic acid 
• 52602-39-8 9H-carbazol-4-ol 
• 787598-91-8 (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate 

Relevant articles and documents

Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug

Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright

PROCESS FOR MANUFACTURE OF RACEMIC CARVEDILOL

The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5 %) having individual impurity less than 0.1 %. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.