91892-60-3

Upstream product

• 10409-78-6 N²,N²,N⁴,N⁴-tetramethyl-2,4-diamino-6-hydrazinyl-[1,3,5]triazine 
• 91892-42-1 2-(4-chlorobenzylidenehydrazino)-4,6-bis(dimethylamino)-1,3,5-triazine 
• 104-88-1 4-chlorobenzaldehyde 
• 91892-51-2 3-(4-chlorophenyl)-5,7-bis(dimethylamino)-1,2,4-triazolo<4,3-a><1,3,5>triazine 

Relevant academic research and scientific papers

Triazines and Related Products. Part 26. Synthesis and Chemistry of Bicyclic Analogues of the Antitumour Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine (Hexamethylmelamine)

Interaction of 2,4-bis(dimethylamino)-6-hydrazino-1,3,5-triazine (1c) with aryl aldehydes yields a series of aryl hydrazones (4) which cyclise to 3-aryl-5,7-bis(dimethylamino)-1,2,4-triazolotriazines (6) with lead(VI) acetate in dichloromethane.Rearrangement of these bicycles in methanolic sodium hydroxide affords stable isomeric 2-aryl-5,7-bis(dimethylamino)triazolotriazines (7).Selected examples from both series of triazolotriazines were screened against the mouse M5076 reticulum cell sarcoma and P388 leukaemia in vivo but proved to have no antitumour activity.