918931-51-8Relevant articles and documents
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Kurukulasuriya, Ravi,Rohde, Jeffrey J.,Szczepankiewicz, Bruce G.,Basha, Fatima,Lai, Chunqui,Jae, Hwan-Soo,Winn, Martin,Stewart, Kent D.,Longenecker, Kenton L.,Lubben, Thomas W.,Ballaron, Stephen J.,Sham, Hing L.,von Geldern, Thomas W.
, p. 6226 - 6230 (2006)
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV Ki = 2 nM) and exhibits excellent selectivity and no species specificity aga