91897-95-9Relevant academic research and scientific papers
QSAR Analysis for ADA upon Interaction with a Series of Adenine Derivatives as Inhibitors
Moosavi-Movahedi,Safarian,Hakimelahi,Ataei,Ajloo,Panjehpour,Riahi,Mousavi,Mardanyan,Soltani,Khalafi-Nezhad,Sharghi,Moghadamnia,Saboury
, p. 613 - 624 (2007/10/03)
The kinetic parameters of adenosine deaminase such as Km and Ki were determined in the absence and presence of adenine derivatives (R1- R24) in sodium phosphate buffer (50 mM; pH 7.5) solution at 27°C. These kinetic parameters were used for QSAR analysis. As such, we found some theoretical descriptors to which the binding affinity of adenosine deaminase (ADA) towards several adenine nucleosides as inhibitors is correlated. QSAR analysis has revealed that binding affinity of the adenine nucleosides upon interaction with ADA depends on the molecular volume, dipole moment of the molecule, electric charge around the N1 atom, and the highest of positive charge for the related molecules.
Nucleic Acid Related Compounds. 47. Synthesis and Biological Activities of Pyrimidine and Purine "Acyclic" Nucleoside Analogues
Robins, Morris J.,Hatfield, Peter W.,Balzarini, Jan,Clercq, Eric De
, p. 1486 - 1492 (2007/10/02)
Various acyclic, i.e., (2-hydroxyethoxy)methyl and (2-acetoxyethoxy)methyl, analogues of pyrimidine and purine nucleosides have been prepared evaluated for their antiviral, antimetabolic, and cytotoxic properties.All of the pyrimidine analogues, including (E)-5-(2-bromovinyl)-1-uracil (12) and its O-acetyl derivative (13), were virtually devoid of antiviral, cytotoxic, and antimetabolic activities.However, several of the 8-substituted derivatives of 9-guanine (acyclovir) had higher antiviral specificity in vitro than the parent drug.The 8-methyl-, 8-amino-, 8-bromo-, and 8-iodoacyclovir derivatives have activities worthy of further investigation.
