919077-01-3Relevant academic research and scientific papers
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists
Hertzog, Donald L.,Al-Barazanji, Kamal A.,Bigham, Eric C.,Bishop, Michael J.,Britt, Christy S.,Carlton, David L.,Cooper, Joel P.,Daniels, Alex J.,Garrido, Dulce M.,Goetz, Aaron S.,Grizzle, Mary K.,Guo, Yu C.,Handlon, Anthony L.,Ignar, Diane M.,Morgan, Ronda O.,Peat, Andrew J.,Tavares, Francis X.,Zhou, Huiqiang
, p. 4723 - 4727 (2007/10/03)
Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in
